Auto-Save every X minutes (or seconds) This probably is not what you want, although there is no harm in setting it. However, even if you don't use Keyboard Maestro, I encourage you to read on, because I'm going to offer another suggestion at the end.
As I was writing this article, it also occurred to me that I would like to save when Microsoft Word deactivates (is no longer the front-most app). thesis in Microsoft Word, I already had a macro for that. That led her to make a comment about intending to write a Keyboard Maestro macro to save every minute when using Microsoft Word. Around the 38m40s mark, Katie mentioned that she uses Word a lot in her day job, and has a lot of issues with the app freezing up periodically. In Mac Power Users Episode 187, David Sparks and Katie Floyd talked about word processing apps, which meant talking a great deal about Microsoft Word, as well as Pages and others.